Lysophosphatidic Acid Augments the Gene Expression and Production of Matrix Metalloproteinases-1 and -3 in Human Synovial Fibroblasts <i>in Vitro</i>

Rheumatoid arthritis (RA) is an inflammatory disease with joint dysfunction following cartilage degradation. The level of lysophosphatidic acid (LPA) has been reported to be augmented in human synovial fluid from patients RA. However, it remains elucidated whether LPA participates destruction. In the present study, we have demonstrated that production promatrix metalloproteinases (proMMPs)-1 and -3 was along increase extracellular signal-regulated kinase (ERK)1/2 phosphorylation through receptor 1 (LPAR1) fibroblasts. These results suggest transcriptionally increases MMP by activation LPAR1/ERK1/2 signal pathway Thus, likely a pathological candidate for degradation